Assay Detail
Binding
CHEMBL1805783
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TPA-induced cPLA2alpha activity in human platelets assessed as inhibition of arachidonic acid production after 60 mins by UV-reverse phase HPLC analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
1-(5-Carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A2α: effect of substituents in position 3 of the indole scaffold on inhibitory potency, metabolic stability, solubility, and bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.22 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1800085 | — | — | 1 | 9.22 |
| CHEMBL30108 | — | — | 1 | 8.33 |
| CHEMBL1801026 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1800085 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL30108 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL1801026 | — | IC50 | = | 76.0 | nM | 7.12 |