Assay Detail
Binding
CHEMBL1805904
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Inhibition of JNK2
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.85 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1801376 | — | — | 1 | 9.00 |
| CHEMBL1801373 | — | — | 1 | 8.70 |
| CHEMBL1801380 | — | — | 1 | 7.96 |
| CHEMBL1801374 | — | — | 1 | 7.66 |
| CHEMBL1801378 | — | — | 1 | 7.52 |
| CHEMBL1801375 | — | — | 1 | 7.47 |
| CHEMBL1801382 | — | — | 1 | 7.42 |
| CHEMBL1801385 | — | — | 1 | 7.12 |
| CHEMBL1801381 | — | — | 1 | 7.12 |
| CHEMBL1801390 | — | — | 1 | 7.07 |
| CHEMBL1801384 | — | — | 1 | 6.70 |
| CHEMBL1801387 | — | — | 1 | 6.57 |
| CHEMBL1801388 | — | — | 1 | 6.38 |
| CHEMBL1801316 | — | — | 1 | 6.26 |
| CHEMBL1614995 | — | — | 1 | 6.19 |
| CHEMBL1801392 | — | — | 1 | 6.16 |
| CHEMBL1801391 | — | — | 1 | 6.01 |
| CHEMBL1801386 | — | — | 1 | 5.85 |
| CHEMBL1801389 | — | — | 1 | 5.66 |
| CHEMBL1801090 | — | — | 1 | 5.57 |
| CHEMBL1801089 | — | — | 1 | 5.50 |
| CHEMBL1801091 | — | — | 1 | - |
| CHEMBL1801088 | — | — | 1 | - |
| CHEMBL1801383 | — | — | 1 | - |
| CHEMBL1801313 | — | — | 1 | - |
| CHEMBL1801379 | — | — | 1 | - |
| CHEMBL1801377 | — | — | 1 | - |
| CHEMBL1801315 | — | — | 1 | - |
| CHEMBL1801314 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1801376 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1801373 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1801380 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1801374 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1801378 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1801375 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1801382 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1801385 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1801381 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1801390 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1801384 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL1801387 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL1801388 | — | IC50 | = | 418.0 | nM | 6.38 |
| CHEMBL1801316 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL1614995 | — | IC50 | = | 649.0 | nM | 6.19 |
| CHEMBL1801392 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1801391 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL1801386 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL1801389 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1801090 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1801089 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL1801091 | — | IC50 | - | — | - | |
| CHEMBL1801088 | — | IC50 | - | — | - | |
| CHEMBL1801383 | — | IC50 | - | — | - | |
| CHEMBL1801313 | — | IC50 | - | — | - | |
| CHEMBL1801379 | — | IC50 | - | — | - | |
| CHEMBL1801377 | — | IC50 | - | — | - | |
| CHEMBL1801315 | — | IC50 | - | — | - | |
| CHEMBL1801314 | — | IC50 | - | — | - |