Assay Detail
Functional
CHEMBL1806025
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human CXCR4 expressed in human U87 cells expressing CD4 assessed as inhibition of CXCL12-induced cAMP production pretreated for 15 mins before forskolin challenge by TR-FRET analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.07 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802333 | — | — | 1 | 9.10 |
| CHEMBL237830 | — | — | 1 | 8.74 |
| CHEMBL1802329 | — | — | 1 | 8.27 |
| CHEMBL2311028 | PLERIXAFOR OCTAHYDROCHLORIDE | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802333 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL237830 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1802329 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL2311028 | PLERIXAFOR OCTAHYDROCHLORIDE | IC50 | = | 695.0 | nM | 6.16 |