Assay Detail
Functional
CHEMBL1806080
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Cytotoxicity against human SKBR3 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.37 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1801578 | — | — | 1 | 7.92 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.60 |
| CHEMBL365617 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1801578 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL109480 | TANESPIMYCIN | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL365617 | — | EC50 | = | 250.0 | nM | 6.60 |