Assay Detail
Binding
CHEMBL1806177
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Hsp90alpha in human SKBR3 cells assessed as up-regulation of HSP70 protein by Western blot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.91 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.22 |
| CHEMBL1801578 | — | — | 1 | 7.22 |
| CHEMBL365617 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1801578 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL365617 | — | EC50 | = | 500.0 | nM | 6.30 |