Assay Detail
Functional
CHEMBL1806219
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GFP tagged-human P2Y1 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.73 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | 6.82 |
| CHEMBL1802094 | — | — | 1 | 6.52 |
| CHEMBL1802096 | — | — | 1 | 5.05 |
| CHEMBL1802097 | — | — | 1 | 4.52 |
| CHEMBL1802095 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1802094 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1802096 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1802097 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1802095 | — | EC50 | >= | 30000.0 | nM | - |