Assay Detail
Binding
CHEMBL1809754
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Inhibition of bovine liver beta glucuronidase assessed as p-nitrophenol formation after 30 mins by spectrophotometric method
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of novel inhibitors of β-glucuronidase based on benzothiazole skeleton and study of their binding affinity by molecular docking.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 8 | - | - |
| IC50 | 8 | 4.83 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1808311 | — | — | 1 | 5.65 |
| CHEMBL1650632 | — | — | 1 | 5.37 |
| CHEMBL47875 | — | — | 1 | 5.05 |
| CHEMBL1808308 | — | — | 1 | 5.05 |
| CHEMBL1408767 | — | — | 1 | 4.71 |
| CHEMBL149322 | — | — | 1 | 4.44 |
| CHEMBL1808316 | D-SACCHARIC ACID 1,4-LACTONE | — | 1 | 4.32 |
| CHEMBL437134 | — | — | 1 | 4.03 |
| CHEMBL1808305 | — | — | 1 | - |
| CHEMBL1808309 | — | — | 1 | - |
| CHEMBL201610 | — | — | 1 | - |
| CHEMBL92816 | — | — | 1 | - |
| CHEMBL1440893 | — | — | 1 | - |
| CHEMBL1808312 | — | — | 1 | - |
| CHEMBL1808313 | — | — | 1 | - |
| CHEMBL1808314 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1808311 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL1650632 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL47875 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1808308 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1408767 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL149322 | — | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL1808316 | D-SACCHARIC ACID 1,4-LACTONE | IC50 | = | 48400.0 | nM | 4.32 |
| CHEMBL437134 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL1808305 | — | Inhibition | - | % | - | |
| CHEMBL1808309 | — | Inhibition | - | % | - | |
| CHEMBL201610 | — | Inhibition | - | % | - | |
| CHEMBL92816 | — | Inhibition | - | % | - | |
| CHEMBL1440893 | — | Inhibition | - | % | - | |
| CHEMBL1808312 | — | Inhibition | - | % | - | |
| CHEMBL1808313 | — | Inhibition | - | % | - | |
| CHEMBL1808314 | — | Inhibition | - | % | - |