Assay Detail
Binding
CHEMBL1809823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARalpha ligand binding domain expressed in HEK293 cells co-expressing GAL4 after 18 hrs by dual-luciferase activity based transactivation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzothiazole-based N-(phenylsulfonyl)amides as a novel family of PPARα antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.09 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21241 | GW7647 | — | 1 | 6.70 |
| CHEMBL1808555 | — | — | 1 | 4.30 |
| CHEMBL683 | CLOFIBRIC ACID | 2.0 | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21241 | GW7647 | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1808555 | — | EC50 | = | 50600.0 | nM | 4.30 |
| CHEMBL683 | CLOFIBRIC ACID | EC50 | = | 55000.0 | nM | 4.26 |