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Assay Detail

CHEMBL1810090

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives.
Singh P, Sachdeva S, Raj R, Kumar V, Mahajan MP, Nasser S, Vivas L, Gut J, Rosenthal PJ, Feng TS, Chibale K.
Bioorg Med Chem Lett (2011) 21 : 4561 -4563
PubMed 21705220 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.31 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 8.70
CHEMBL1807628 1 5.63
CHEMBL1807627 1 5.35
CHEMBL1807629 1 5.33
CHEMBL1807626 1 5.23
CHEMBL1807625 1 4.99
CHEMBL1807631 1 4.73
CHEMBL1807633 1 4.53
CHEMBL1807630 1 4.42
CHEMBL1807632 1 4.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 2.0 nM 8.70
CHEMBL1807628 IC50 = 2360.0 nM 5.63
CHEMBL1807627 IC50 = 4470.0 nM 5.35
CHEMBL1807629 IC50 = 4700.0 nM 5.33
CHEMBL1807626 IC50 = 5830.0 nM 5.23
CHEMBL1807625 IC50 = 10350.0 nM 4.99
CHEMBL1807631 IC50 = 18590.0 nM 4.73
CHEMBL1807633 IC50 = 29280.0 nM 4.53
CHEMBL1807630 IC50 = 38060.0 nM 4.42
CHEMBL1807632 IC50 = 59850.0 nM 4.22