Assay Detail
Functional
CHEMBL1810092
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.87 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.92 |
| CHEMBL1807750 | — | — | 1 | 5.92 |
| CHEMBL1807752 | — | — | 1 | 5.47 |
| CHEMBL1807751 | — | — | 1 | 5.15 |
| CHEMBL1807636 | — | — | 1 | 4.91 |
| CHEMBL1807634 | — | — | 1 | - |
| CHEMBL1807635 | — | — | 1 | - |
| CHEMBL1807749 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1807750 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL1807752 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL1807751 | — | IC50 | = | 7090.0 | nM | 5.15 |
| CHEMBL1807636 | — | IC50 | = | 12270.0 | nM | 4.91 |
| CHEMBL1807634 | — | IC50 | - | — | - | |
| CHEMBL1807635 | — | IC50 | > | 45660.0 | nM | - |
| CHEMBL1807749 | — | IC50 | > | 51020.0 | nM | - |