Assay Detail
Functional
CHEMBL1810097
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Cytotoxicity against human KB cells assessed as growth inhibition
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.17 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 9.30 |
| CHEMBL1807750 | — | — | 1 | 5.08 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.44 |
| CHEMBL1807751 | — | — | 1 | 4.08 |
| CHEMBL1807752 | — | — | 1 | 4.05 |
| CHEMBL1807749 | — | — | 1 | 4.04 |
| CHEMBL1807634 | — | — | 1 | - |
| CHEMBL1807635 | — | — | 1 | - |
| CHEMBL1807636 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1807750 | — | IC50 | = | 8360.0 | nM | 5.08 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 35950.0 | nM | 4.44 |
| CHEMBL1807751 | — | IC50 | = | 84170.0 | nM | 4.08 |
| CHEMBL1807752 | — | IC50 | = | 89150.0 | nM | 4.05 |
| CHEMBL1807749 | — | IC50 | = | 91250.0 | nM | 4.04 |
| CHEMBL1807634 | — | IC50 | - | — | - | |
| CHEMBL1807635 | — | IC50 | > | 228310.0 | nM | - |
| CHEMBL1807636 | — | IC50 | = | 145290.0 | nM | - |