Assay Detail
Binding
CHEMBL1810119
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Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New substrate analogue furin inhibitors derived from 4-amidinobenzylamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.52 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566340 | — | — | 1 | 9.09 |
| CHEMBL1808902 | — | — | 1 | 9.08 |
| CHEMBL1808903 | — | — | 1 | 9.08 |
| CHEMBL1808904 | — | — | 1 | 8.85 |
| CHEMBL1808933 | — | — | 1 | 8.82 |
| CHEMBL1808905 | — | — | 1 | 8.72 |
| CHEMBL1808906 | — | — | 1 | 8.52 |
| CHEMBL1808907 | — | — | 1 | 8.52 |
| CHEMBL1808908 | — | — | 1 | 8.44 |
| CHEMBL1808934 | — | — | 1 | 8.43 |
| CHEMBL1808909 | — | — | 1 | 8.23 |
| CHEMBL1808910 | — | — | 1 | 8.22 |
| CHEMBL1808912 | — | — | 1 | 8.20 |
| CHEMBL1808911 | — | — | 1 | 8.20 |
| CHEMBL1808913 | — | — | 1 | 8.01 |
| CHEMBL1808914 | — | — | 1 | 7.92 |
| CHEMBL1808915 | — | — | 1 | 7.89 |
| CHEMBL1808916 | — | — | 1 | 7.72 |
| CHEMBL1808917 | — | — | 1 | 7.64 |
| CHEMBL1808918 | — | — | 1 | 7.62 |
| CHEMBL1808919 | — | — | 1 | 7.43 |
| CHEMBL1808920 | — | — | 1 | 7.40 |
| CHEMBL1808921 | — | — | 1 | 6.99 |
| CHEMBL1808932 | — | — | 1 | 6.85 |
| CHEMBL1808924 | — | — | 1 | 6.62 |
| CHEMBL1808923 | — | — | 1 | 6.54 |
| CHEMBL1808922 | — | — | 1 | 6.39 |
| CHEMBL1808925 | — | — | 1 | 6.15 |
| CHEMBL1808928 | — | — | 1 | 6.01 |
| CHEMBL1808926 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566340 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL1808902 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL1808903 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL1808904 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1808933 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1808905 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1808906 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1808907 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1808908 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1808934 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL1808909 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL1808910 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1808912 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL1808911 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL1808913 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL1808914 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1808915 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1808916 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1808917 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1808918 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1808919 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1808920 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL1808921 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL1808932 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL1808924 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL1808923 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL1808922 | — | Ki | = | 405.0 | nM | 6.39 |
| CHEMBL1808925 | — | Ki | = | 702.0 | nM | 6.15 |
| CHEMBL1808928 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL1808926 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL1808927 | — | Ki | = | 1385.0 | nM | 5.86 |
| CHEMBL1808930 | — | Ki | = | 2390.0 | nM | 5.62 |
| CHEMBL1808931 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL1808929 | — | Ki | = | 7340.0 | nM | 5.13 |