Assay Detail
Functional
CHEMBL1810210
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Antiproliferative activity against human NCI-H460 cells assessed as viable cells after 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.86 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98745 | NARCICLASINE | — | 1 | 7.40 |
| CHEMBL1808972 | — | — | 1 | 7.16 |
| CHEMBL1808971 | — | — | 1 | 7.05 |
| CHEMBL1808969 | — | — | 1 | 6.40 |
| CHEMBL1808970 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98745 | NARCICLASINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1808972 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1808971 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1808969 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1808970 | — | IC50 | = | 530.0 | nM | 6.28 |