Assay Detail
Binding
CHEMBL1810317
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ex vivo receptor occupancy of CXCR3 in rat blood assessed as inhibition of ITAC binding after 1 hr by flow cytometry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
C-X-C chemokine receptor type 3 (CHEMBL1075172) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.38 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1809039 | — | — | 1 | 8.30 |
| CHEMBL1809038 | — | — | 1 | 8.15 |
| CHEMBL1809040 | — | — | 1 | 7.85 |
| CHEMBL1809041 | — | — | 1 | 7.80 |
| CHEMBL1809042 | — | — | 1 | 7.64 |
| CHEMBL1809043 | — | — | 1 | 7.40 |
| CHEMBL1809011 | — | — | 1 | 6.39 |
| CHEMBL1806523 | — | — | 1 | 5.48 |
| CHEMBL1809037 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1809039 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1809038 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1809040 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1809041 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1809042 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1809043 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1809011 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1806523 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1809037 | — | IC50 | - | — | - |