Assay Detail
Binding
CHEMBL1810319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radiolabeled CXCL11 from human CXCR3 expressed in CHO cells by scintillation proximity assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 7.24 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1809041 | — | — | 1 | 8.70 |
| CHEMBL1809039 | — | — | 1 | 8.70 |
| CHEMBL1809040 | — | — | 1 | 8.52 |
| CHEMBL1809016 | — | — | 1 | 8.40 |
| CHEMBL1806523 | — | — | 1 | 8.30 |
| CHEMBL1809042 | — | — | 1 | 8.30 |
| CHEMBL1809038 | — | — | 1 | 8.22 |
| CHEMBL1809017 | — | — | 1 | 8.15 |
| CHEMBL1809000 | — | — | 1 | 8.05 |
| CHEMBL1809003 | — | — | 1 | 7.92 |
| CHEMBL1809011 | — | — | 1 | 7.85 |
| CHEMBL1809002 | — | — | 1 | 7.77 |
| CHEMBL1809008 | — | — | 1 | 7.66 |
| CHEMBL1809043 | — | — | 1 | 7.62 |
| CHEMBL1809028 | — | — | 1 | 7.62 |
| CHEMBL1809024 | — | — | 1 | 7.58 |
| CHEMBL1809029 | — | — | 1 | 7.55 |
| CHEMBL1808996 | — | — | 1 | 7.55 |
| CHEMBL1809025 | — | — | 1 | 7.43 |
| CHEMBL1809015 | — | — | 1 | 7.37 |
| CHEMBL1809014 | — | — | 1 | 7.33 |
| CHEMBL1809012 | — | — | 1 | 7.30 |
| CHEMBL584554 | — | — | 1 | 7.29 |
| CHEMBL1809013 | — | — | 1 | 7.21 |
| CHEMBL1808999 | — | — | 1 | 7.21 |
| CHEMBL1808998 | — | — | 1 | 7.18 |
| CHEMBL1809001 | — | — | 1 | 7.09 |
| CHEMBL1809006 | — | — | 1 | 6.88 |
| CHEMBL1809037 | — | — | 1 | 6.84 |
| CHEMBL1809027 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1809041 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1809039 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1809040 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1809016 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1806523 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1809042 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1809038 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1809017 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1809000 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1809003 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1809011 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1809002 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1809008 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1809028 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1809043 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1809024 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1809029 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1808996 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1809025 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1809015 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1809014 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1809012 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL584554 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1809013 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1808999 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1808998 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1809001 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1809006 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL1809037 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL1809027 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1809005 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL1809019 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL1808997 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL1808995 | — | IC50 | = | 379.0 | nM | 6.42 |
| CHEMBL1809020 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL1809010 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1809036 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL1809018 | — | IC50 | = | 523.0 | nM | 6.28 |
| CHEMBL1809007 | — | IC50 | = | 825.0 | nM | 6.08 |
| CHEMBL1809004 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL1809009 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL1809033 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1809034 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1809030 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1809031 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1809032 | — | IC50 | - | — | - | |
| CHEMBL1809035 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1809026 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1809023 | — | IC50 | - | — | - | |
| CHEMBL1809022 | — | IC50 | - | — | - |