Assay Detail
Functional
CHEMBL1810320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human CXCR3 expressed in mouse L1.2 cells assessed as inhibition of ITAC-induced calcium mobilization by FLIPR assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | L1.2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 7.40 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1809039 | — | — | 1 | 8.70 |
| CHEMBL1809016 | — | — | 1 | 8.52 |
| CHEMBL1809002 | — | — | 1 | 8.52 |
| CHEMBL1809040 | — | — | 1 | 8.52 |
| CHEMBL1809017 | — | — | 1 | 8.40 |
| CHEMBL1806523 | — | — | 1 | 8.40 |
| CHEMBL1809003 | — | — | 1 | 8.40 |
| CHEMBL1809042 | — | — | 1 | 8.30 |
| CHEMBL1809041 | — | — | 1 | 8.30 |
| CHEMBL1809011 | — | — | 1 | 8.30 |
| CHEMBL1809038 | — | — | 1 | 8.30 |
| CHEMBL1809000 | — | — | 1 | 8.30 |
| CHEMBL1809024 | — | — | 1 | 8.15 |
| CHEMBL1809043 | — | — | 1 | 8.10 |
| CHEMBL1809025 | — | — | 1 | 8.10 |
| CHEMBL1808999 | — | — | 1 | 8.10 |
| CHEMBL1808996 | — | — | 1 | 8.00 |
| CHEMBL1809028 | — | — | 1 | 7.96 |
| CHEMBL1808998 | — | — | 1 | 7.92 |
| CHEMBL1809014 | — | — | 1 | 7.92 |
| CHEMBL1809001 | — | — | 1 | 7.85 |
| CHEMBL1809029 | — | — | 1 | 7.85 |
| CHEMBL1809008 | — | — | 1 | 7.80 |
| CHEMBL584554 | — | — | 1 | 7.75 |
| CHEMBL1809015 | — | — | 1 | 7.70 |
| CHEMBL1809013 | — | — | 1 | 7.66 |
| CHEMBL1809019 | — | — | 1 | 7.57 |
| CHEMBL1809037 | — | — | 1 | 7.28 |
| CHEMBL1809018 | — | — | 1 | 7.22 |
| CHEMBL1809010 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1809039 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1809016 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1809040 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1809002 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1809017 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1806523 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1809003 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1809042 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1809041 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1809011 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1809038 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1809000 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1809024 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1809025 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1809043 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1808999 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1808996 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1809028 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1808998 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1809014 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1809001 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1809029 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1809008 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL584554 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1809015 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1809013 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1809019 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1809037 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1809018 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1809010 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1808995 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1809027 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1809005 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1809006 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1809020 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1809036 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1808997 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL1809012 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1809009 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL1809007 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL1809004 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL1809033 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1809023 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1809035 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL1809022 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1809030 | — | IC50 | = | 9475.0 | nM | 5.02 |
| CHEMBL1809034 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1809021 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1808994 | — | IC50 | - | — | - | |
| CHEMBL1809032 | — | IC50 | > | 10000.0 | nM | - |