Assay Detail
Functional
CHEMBL1810322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CXCR3 in rat leukocytes assessed as inhibition of ITAC-induced cell migration by flow cytometry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
C-X-C chemokine receptor type 3 (CHEMBL1075172) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.46 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1809000 | — | — | 1 | 7.89 |
| CHEMBL1806523 | — | — | 1 | 7.72 |
| CHEMBL584554 | — | — | 1 | 7.13 |
| CHEMBL1809008 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1809000 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1806523 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL584554 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1809008 | — | IC50 | = | 78.0 | nM | 7.11 |