Assay Detail
Binding
CHEMBL1810428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader analysis
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transmembrane protease serine 11D (CHEMBL1795138) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 7.11 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1809213 | — | — | 1 | 7.89 |
| CHEMBL1809250 | — | — | 1 | 7.85 |
| CHEMBL1809251 | — | — | 1 | 7.82 |
| CHEMBL1809238 | — | — | 1 | 7.77 |
| CHEMBL1229259 | — | — | 1 | 7.72 |
| CHEMBL1809252 | — | — | 1 | 7.66 |
| CHEMBL1809253 | — | — | 1 | 7.64 |
| CHEMBL1809254 | — | — | 1 | 7.52 |
| CHEMBL1809256 | — | — | 1 | 7.47 |
| CHEMBL1809255 | — | — | 1 | 7.47 |
| CHEMBL1809214 | — | — | 1 | 7.44 |
| CHEMBL1809215 | — | — | 1 | 7.42 |
| CHEMBL1809239 | — | — | 1 | 7.42 |
| CHEMBL1809216 | — | — | 1 | 7.40 |
| CHEMBL1809240 | — | — | 1 | 7.37 |
| CHEMBL1809257 | — | — | 1 | 7.33 |
| CHEMBL1809212 | — | — | 1 | 7.29 |
| CHEMBL1809217 | — | — | 1 | 7.28 |
| CHEMBL1809258 | — | — | 1 | 7.24 |
| CHEMBL1809218 | — | — | 1 | 7.20 |
| CHEMBL1809241 | — | — | 1 | 7.17 |
| CHEMBL1809242 | — | — | 1 | 7.14 |
| CHEMBL1809219 | — | — | 1 | 7.12 |
| CHEMBL252937 | — | — | 1 | 7.11 |
| CHEMBL1809220 | — | — | 1 | 7.01 |
| CHEMBL1229261 | — | — | 1 | 6.97 |
| CHEMBL1809234 | — | — | 1 | 6.92 |
| CHEMBL1809243 | — | — | 1 | 6.87 |
| CHEMBL1809244 | — | — | 1 | 6.83 |
| CHEMBL1809245 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1809213 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1809250 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL1809251 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1809238 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1229259 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1809252 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1809253 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1809254 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1809256 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL1809255 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL1809214 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL1809215 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1809239 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1809216 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL1809240 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL1809257 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL1809212 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL1809217 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL1809258 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL1809218 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL1809241 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL1809242 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL1809219 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL252937 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL1809220 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL1229261 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL1809234 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL1809243 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL1809244 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL1809245 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL1809235 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL1809246 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL1809247 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL1809248 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL1809249 | — | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL1809236 | — | Ki | = | 311.0 | nM | 6.51 |
| CHEMBL1809259 | — | Ki | = | 422.0 | nM | 6.38 |
| CHEMBL1809211 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL1809260 | — | Ki | = | 457.0 | nM | 6.34 |
| CHEMBL1809261 | — | Ki | = | 512.0 | nM | 6.29 |
| CHEMBL1809237 | — | Ki | = | 1425.0 | nM | 5.85 |