Assay Detail
Functional
CHEMBL1810652
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Inhibition of TNF-alpha-induced proMMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.95 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225703 | — | — | 1 | 5.26 |
| CHEMBL438292 | — | — | 1 | 4.97 |
| CHEMBL225704 | — | — | 1 | 4.79 |
| CHEMBL76447 | NOBILETIN | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225703 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL438292 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL225704 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL76447 | NOBILETIN | IC50 | = | 17000.0 | nM | 4.77 |