Assay Detail
Functional
CHEMBL1810686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HeLa cells assessed as inhibition of cell survival after 72 hrs by MTT method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative activity of aroylacrylic acids. Structure-activity study based on molecular interaction fields.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.01 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1806610 | — | — | 1 | 5.90 |
| CHEMBL1806609 | — | — | 1 | 5.62 |
| CHEMBL1806604 | — | — | 1 | 5.39 |
| CHEMBL1806596 | — | — | 1 | 5.32 |
| CHEMBL1806605 | — | — | 1 | 5.32 |
| CHEMBL1806595 | — | — | 1 | 5.31 |
| CHEMBL1806603 | — | — | 1 | 5.31 |
| CHEMBL1806597 | — | — | 1 | 5.29 |
| CHEMBL1806598 | — | — | 1 | 5.24 |
| CHEMBL1806599 | — | — | 1 | 5.22 |
| CHEMBL1806607 | — | — | 1 | 5.21 |
| CHEMBL1806606 | — | — | 1 | 5.18 |
| CHEMBL1806602 | — | — | 1 | 5.15 |
| CHEMBL1806601 | — | — | 1 | 5.14 |
| CHEMBL44664 | — | — | 1 | 5.12 |
| CHEMBL1806611 | — | — | 1 | 5.12 |
| CHEMBL1806608 | — | — | 1 | 5.12 |
| CHEMBL1806600 | — | — | 1 | 5.11 |
| CHEMBL1806614 | — | — | 1 | 4.73 |
| CHEMBL1806613 | — | — | 1 | 4.59 |
| CHEMBL1806594 | — | — | 1 | 4.56 |
| CHEMBL1806616 | — | — | 1 | 4.56 |
| CHEMBL1806612 | — | — | 1 | 4.55 |
| CHEMBL98963 | — | — | 1 | 4.55 |
| CHEMBL16365 | — | — | 1 | 4.51 |
| CHEMBL1806615 | — | — | 1 | 4.20 |
| CHEMBL1806617 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1806610 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL1806609 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL1806604 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL1806596 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL1806605 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL1806595 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1806603 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL1806597 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1806598 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL1806599 | — | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL1806607 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1806606 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL1806602 | — | IC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL1806601 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL44664 | — | IC50 | = | 7620.0 | nM | 5.12 |
| CHEMBL1806611 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL1806608 | — | IC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL1806600 | — | IC50 | = | 7860.0 | nM | 5.11 |
| CHEMBL1806614 | — | IC50 | = | 18680.0 | nM | 4.73 |
| CHEMBL1806613 | — | IC50 | = | 25420.0 | nM | 4.59 |
| CHEMBL1806594 | — | IC50 | = | 27790.0 | nM | 4.56 |
| CHEMBL1806616 | — | IC50 | = | 27360.0 | nM | 4.56 |
| CHEMBL1806612 | — | IC50 | = | 28410.0 | nM | 4.55 |
| CHEMBL98963 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL16365 | — | IC50 | = | 30640.0 | nM | 4.51 |
| CHEMBL1806615 | — | IC50 | = | 62940.0 | nM | 4.20 |
| CHEMBL1806617 | — | IC50 | = | 96180.0 | nM | 4.02 |