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Assay Detail

CHEMBL1810896

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Binding
Inhibition of Staphylococcus aureus LigA by FRET-based assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Staphylococcus aureus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of bacterial NAD+-dependent DNA ligase inhibitors: optimization of antibacterial activity.
Stokes SS, Huynh H, Gowravaram M, Albert R, Cavero-Tomas M, Chen B, Harang J, Loch JT, Lu M, Mullen GB, Zhao S, Liu CF, Mills SD.
Bioorg Med Chem Lett (2011) 21 : 4556 -4560
PubMed 21719282 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.88 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1807860 1 7.52
CHEMBL1807856 1 7.40
CHEMBL1807849 1 7.22
CHEMBL1807851 1 7.22
CHEMBL1233689 1 7.10
CHEMBL1807857 1 7.05
CHEMBL1807858 1 6.96
CHEMBL1807816 1 6.92
CHEMBL1807848 1 6.92
CHEMBL1807852 1 6.89
CHEMBL1807859 1 6.89
CHEMBL1807854 1 6.85
CHEMBL1807850 1 6.80
CHEMBL1807814 1 6.77
CHEMBL1807853 1 6.43
CHEMBL576883 1 6.42
CHEMBL1807815 1 6.37
CHEMBL1807855 1 6.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1807860 IC50 = 30.0 nM 7.52
CHEMBL1807856 IC50 = 40.0 nM 7.40
CHEMBL1807849 IC50 = 60.0 nM 7.22
CHEMBL1807851 IC50 = 60.0 nM 7.22
CHEMBL1233689 IC50 = 80.0 nM 7.10
CHEMBL1807857 IC50 = 90.0 nM 7.05
CHEMBL1807858 IC50 = 110.0 nM 6.96
CHEMBL1807816 IC50 = 120.0 nM 6.92
CHEMBL1807848 IC50 = 120.0 nM 6.92
CHEMBL1807852 IC50 = 130.0 nM 6.89
CHEMBL1807859 IC50 = 130.0 nM 6.89
CHEMBL1807854 IC50 = 140.0 nM 6.85
CHEMBL1807850 IC50 = 160.0 nM 6.80
CHEMBL1807814 IC50 = 170.0 nM 6.77
CHEMBL1807853 IC50 = 370.0 nM 6.43
CHEMBL576883 IC50 = 380.0 nM 6.42
CHEMBL1807815 IC50 = 430.0 nM 6.37
CHEMBL1807855 IC50 = 910.0 nM 6.04