Assay Detail
Binding
CHEMBL1811056
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Inhibition of CDK2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.81 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73303 | — | — | 1 | 9.00 |
| CHEMBL1809191 | — | — | 1 | 7.11 |
| CHEMBL1809044 | — | — | 1 | 5.96 |
| CHEMBL1809194 | — | — | 1 | 5.96 |
| CHEMBL1809193 | — | — | 1 | 5.57 |
| CHEMBL1809195 | — | — | 1 | 5.00 |
| CHEMBL1809196 | — | — | 1 | 4.80 |
| CHEMBL1806525 | — | — | 1 | 4.57 |
| CHEMBL1809197 | — | — | 1 | 4.28 |
| CHEMBL1809192 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73303 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1809191 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1809044 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1809194 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1809193 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1809195 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1809196 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1806525 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1809197 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL1809192 | — | IC50 | > | 100000.0 | nM | - |