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Assay Detail

CHEMBL1811202

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant MIF tautomerase activity using 4-hydroxyphenylpyruvate as substrate
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Macrophage migration inhibitory factor (CHEMBL2085)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Benzisothiazolones as modulators of macrophage migration inhibitory factor.
Jorgensen WL, Trofimov A, Du X, Hare AA, Leng L, Bucala R.
Bioorg Med Chem Lett (2011) 21 : 4545 -4549
PubMed 21719283 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.29 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1807940 1 6.00
CHEMBL1807864 1 5.72
CHEMBL1807866 1 5.64
CHEMBL1807863 1 5.62
CHEMBL1807933 1 5.55
CHEMBL1807862 1 5.55
CHEMBL1807937 1 5.51
CHEMBL524449 1 5.38
CHEMBL1807942 1 5.32
CHEMBL1807932 1 5.31
CHEMBL1807865 1 5.30
CHEMBL1807931 1 5.25
CHEMBL1701846 1 5.25
CHEMBL1807941 1 5.23
CHEMBL1807934 1 5.21
CHEMBL1706034 1 5.21
CHEMBL1314602 1 5.19
CHEMBL1807867 1 5.19
CHEMBL1807930 1 5.18
CHEMBL1807861 1 5.10
CHEMBL1807938 1 5.10
CHEMBL1807935 1 5.07
CHEMBL1807936 1 4.96
CHEMBL1807939 1 4.72
CHEMBL1807868 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1807940 IC50 = 1000.0 nM 6.00
CHEMBL1807864 IC50 = 1900.0 nM 5.72
CHEMBL1807866 IC50 = 2300.0 nM 5.64
CHEMBL1807863 IC50 = 2400.0 nM 5.62
CHEMBL1807933 IC50 = 2800.0 nM 5.55
CHEMBL1807862 IC50 = 2800.0 nM 5.55
CHEMBL1807937 IC50 = 3100.0 nM 5.51
CHEMBL524449 IC50 = 4200.0 nM 5.38
CHEMBL1807942 IC50 = 4800.0 nM 5.32
CHEMBL1807932 IC50 = 4900.0 nM 5.31
CHEMBL1807865 IC50 = 5000.0 nM 5.30
CHEMBL1807931 IC50 = 5600.0 nM 5.25
CHEMBL1701846 IC50 = 5600.0 nM 5.25
CHEMBL1807941 IC50 = 5900.0 nM 5.23
CHEMBL1807934 IC50 = 6200.0 nM 5.21
CHEMBL1706034 IC50 = 6200.0 nM 5.21
CHEMBL1314602 IC50 = 6500.0 nM 5.19
CHEMBL1807867 IC50 = 6400.0 nM 5.19
CHEMBL1807930 IC50 = 6600.0 nM 5.18
CHEMBL1807861 IC50 = 8000.0 nM 5.10
CHEMBL1807938 IC50 = 7900.0 nM 5.10
CHEMBL1807935 IC50 = 8500.0 nM 5.07
CHEMBL1807936 IC50 = 11000.0 nM 4.96
CHEMBL1807939 IC50 = 19000.0 nM 4.72
CHEMBL1807868 IC50 = 25000.0 nM 4.60