Assay Detail
Binding
CHEMBL1814966
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.73 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230692 | ADENOSINE DIPHOSPHATE (HYDROXYMETHYL)PYRROLIDINEDIOL | — | 1 | 6.92 |
| CHEMBL1813879 | — | — | 1 | 5.10 |
| CHEMBL1813881 | — | — | 1 | 4.92 |
| CHEMBL1813893 | — | — | 1 | 4.68 |
| CHEMBL115114 | — | — | 1 | 4.66 |
| CHEMBL1814045 | — | — | 1 | 4.60 |
| CHEMBL1813880 | — | — | 1 | 4.58 |
| CHEMBL1814046 | — | — | 1 | 4.58 |
| CHEMBL1813892 | — | — | 1 | 4.57 |
| CHEMBL1813891 | — | — | 1 | 4.38 |
| CHEMBL1813885 | — | — | 1 | 4.21 |
| CHEMBL1814047 | — | — | 1 | 4.21 |
| CHEMBL1813887 | — | — | 1 | 4.14 |
| CHEMBL1813890 | — | — | 1 | - |
| CHEMBL1813884 | — | — | 1 | - |
| CHEMBL1814051 | — | — | 1 | - |
| CHEMBL1813883 | — | — | 1 | - |
| CHEMBL267373 | BENZAMIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230692 | ADENOSINE DIPHOSPHATE (HYDROXYMETHYL)PYRROLIDINEDIOL | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1813879 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1813881 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1813893 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL115114 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1814045 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1813880 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1814046 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1813892 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1813891 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL1813885 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL1814047 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL1813887 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL1813890 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL1813884 | — | IC50 | = | 117000.0 | nM | - |
| CHEMBL1814051 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL1813883 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL267373 | BENZAMIDE | IC50 | > | 1000000.0 | nM | - |