Assay Detail

CHEMBL1815000

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Functional

Antiproliferative activity against human OVCAR3 cell

ChEMBL ↗

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Target

OVCAR-3 (CHEMBL614213) ↗

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OVCAR-3 (CHEMBL614213) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target OVCAR-3

CHEMBL614213

Anchored from Assay target.

Protein identity OVCAR-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	OVCAR-3
Confidence	1 — Organism
Curated By	Autocuration

Target

OVCAR-3 (CHEMBL614213) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid.

Xia Z, Farhana L, Correa RG, Das JK, Castro DJ, Yu J, Oshima RG, Reed JC, Fontana JA, Dawson MI.
J Med Chem (2011) 54 : 3793 -3816
PubMed 21548569 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.89	6.89

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1180	O-DEMETHYLATED ADAPALENE	—	1	6.89

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1180	O-DEMETHYLATED ADAPALENE	IC50	=	130.0	nM	6.89