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Assay Detail

CHEMBL1815047

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Functional
Antimicrobial activity against Pseudomonas aeruginosa PA14 assessed as inhibition of biofilm formation after 24 hrs by spectrophotometry
ChEMBL ↗
130
Total Activities
124
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Pseudomonas aeruginosa
Confidence 1 — Organism
Curated By Autocuration

Target

Pseudomonas aeruginosa (CHEMBL348) ↗
Type ORGANISM
Organism Pseudomonas aeruginosa

Publication

Structure-activity relationship of 2-hydroxy-2-aryl-2,3-dihydro-imidazo[1,2-a]pyrimidinium salts and 2N-substituted 4(5)-aryl-2-amino-1H-imidazoles as inhibitors of biofilm formation by Salmonella Typhimurium and Pseudomonas aeruginosa.
Steenackers HP, Ermolat'ev DS, Savaliya B, Weerdt AD, Coster DD, Shah A, Van der Eycken EV, De Vos DE, Vanderleyden J, De Keersmaecker SC.
Bioorg Med Chem (2011) 19 : 3462 -3473
PubMed 21550812 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 124 4.83 6.16
Inhibition 6 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1814259 — — 1 6.16
CHEMBL1814240 — — 1 6.05
CHEMBL1814254 — — 1 5.92
CHEMBL1814239 — — 1 5.92
CHEMBL1814242 — — 2 5.80
CHEMBL1814365 — — 2 5.51
CHEMBL1814252 — — 2 5.51
CHEMBL1649773 — — 1 5.50
CHEMBL1649772 — — 1 5.46
CHEMBL1814379 — — 1 5.43
CHEMBL1814042 — — 1 5.38
CHEMBL1814374 — — 1 5.36
CHEMBL1814226 — — 1 5.27
CHEMBL1814241 — — 2 5.20
CHEMBL1814041 — — 1 5.20
CHEMBL1814224 — — 1 5.17
CHEMBL1814370 — — 1 5.14
CHEMBL1814371 — — 1 5.10
CHEMBL1814253 — — 1 5.01
CHEMBL1814255 — — 1 4.99
CHEMBL1814383 — — 1 4.98
CHEMBL1814250 — — 1 4.97
CHEMBL1814034 — — 1 4.92
CHEMBL1814033 — — 1 4.91
CHEMBL1814251 — — 2 4.90
CHEMBL1814368 — — 1 4.87
CHEMBL1814227 — — 1 4.84
CHEMBL1814007 — — 1 4.84
CHEMBL1649771 — — 1 4.82
CHEMBL1814209 — — 1 4.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1814259 — IC50 = 700.0 nM 6.16
CHEMBL1814240 — IC50 = 900.0 nM 6.05
CHEMBL1814254 — IC50 = 1200.0 nM 5.92
CHEMBL1814239 — IC50 = 1200.0 nM 5.92
CHEMBL1814242 — IC50 = 1600.0 nM 5.80
CHEMBL1814365 — IC50 = 3100.0 nM 5.51
CHEMBL1814252 — IC50 = 3100.0 nM 5.51
CHEMBL1649773 — IC50 = 3200.0 nM 5.50
CHEMBL1649772 — IC50 = 3500.0 nM 5.46
CHEMBL1814379 — IC50 = 3704.0 nM 5.43
CHEMBL1814042 — IC50 = 4200.0 nM 5.38
CHEMBL1814374 — IC50 = 4400.0 nM 5.36
CHEMBL1814226 — IC50 = 5400.0 nM 5.27
CHEMBL1814241 — IC50 = 6300.0 nM 5.20
CHEMBL1814041 — IC50 = 6300.0 nM 5.20
CHEMBL1814224 — IC50 = 6800.0 nM 5.17
CHEMBL1814370 — IC50 = 7200.0 nM 5.14
CHEMBL1814371 — IC50 = 7900.0 nM 5.10
CHEMBL1814253 — IC50 = 9800.0 nM 5.01
CHEMBL1814255 — IC50 = 10200.0 nM 4.99
CHEMBL1814383 — IC50 = 10520.0 nM 4.98
CHEMBL1814250 — IC50 = 10800.0 nM 4.97
CHEMBL1814034 — IC50 = 12100.0 nM 4.92
CHEMBL1814033 — IC50 = 12400.0 nM 4.91
CHEMBL1814251 — IC50 = 12500.0 nM 4.90
CHEMBL1814368 — IC50 = 13500.0 nM 4.87
CHEMBL1814227 — IC50 = 14400.0 nM 4.84
CHEMBL1814007 — IC50 = 14400.0 nM 4.84
CHEMBL1814209 — IC50 = 15100.0 nM 4.82
CHEMBL1649771 — IC50 = 15000.0 nM 4.82
CHEMBL1814020 — IC50 = 15700.0 nM 4.80
CHEMBL1814376 — IC50 = 15800.0 nM 4.80
CHEMBL1814221 — IC50 = 16400.0 nM 4.79
CHEMBL1814021 — IC50 = 20200.0 nM 4.70
CHEMBL1814369 — IC50 = 20200.0 nM 4.70
CHEMBL1814225 — IC50 = 20400.0 nM 4.69
CHEMBL1814215 — IC50 = 22400.0 nM 4.65
CHEMBL1814035 — IC50 = 22300.0 nM 4.65
CHEMBL1814247 — IC50 = 22900.0 nM 4.64
CHEMBL1814223 — IC50 = 22700.0 nM 4.64
CHEMBL1814372 — IC50 = 25000.0 nM 4.60
CHEMBL1814373 — IC50 = 25000.0 nM 4.60
CHEMBL1814249 — IC50 = 25200.0 nM 4.60
CHEMBL1814248 — IC50 = 25000.0 nM 4.60
CHEMBL1814015 — IC50 = 24900.0 nM 4.60
CHEMBL1814006 — IC50 = 25500.0 nM 4.59
CHEMBL1814377 — IC50 = 26270.0 nM 4.58
CHEMBL1814008 — IC50 = 26800.0 nM 4.57
CHEMBL1811944 — IC50 = 27700.0 nM 4.56
CHEMBL1814213 — IC50 = 29000.0 nM 4.54