Assay Detail
Binding
CHEMBL1815358
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Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP1 subtype (CHEMBL2181) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of selective indole-based prostaglandin D₂ receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.34 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1813120 | — | — | 1 | 5.54 |
| CHEMBL1813116 | — | — | 1 | 5.28 |
| CHEMBL364841 | — | — | 1 | 5.21 |
| CHEMBL1813276 | — | — | 1 | - |
| CHEMBL1813287 | — | — | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL1813115 | — | — | 1 | - |
| CHEMBL1813117 | — | — | 1 | - |
| CHEMBL1813118 | — | — | 1 | - |
| CHEMBL1813119 | — | — | 1 | - |
| CHEMBL1813121 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1813120 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL1813116 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL364841 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL1813276 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1813287 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL6 | INDOMETHACIN | Ki | > | 10000.0 | nM | - |
| CHEMBL1813115 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1813117 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1813118 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1813119 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1813121 | — | Ki | > | 10000.0 | nM | - |