Assay Detail
Binding
CHEMBL1815359
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Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL2488) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of selective indole-based prostaglandin D₂ receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.43 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364841 | — | — | 1 | 7.00 |
| CHEMBL1813115 | — | — | 1 | 6.68 |
| CHEMBL1813118 | — | — | 1 | 6.60 |
| CHEMBL1813119 | — | — | 1 | 6.51 |
| CHEMBL1813117 | — | — | 1 | 6.48 |
| CHEMBL1813116 | — | — | 1 | 6.47 |
| CHEMBL1813276 | — | — | 1 | 6.43 |
| CHEMBL1813120 | — | — | 1 | 6.30 |
| CHEMBL1813121 | — | — | 1 | 6.22 |
| CHEMBL1813287 | — | — | 1 | 5.57 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364841 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL1813115 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL1813118 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1813119 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL1813117 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL1813116 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL1813276 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL1813120 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL1813121 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL1813287 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL6 | INDOMETHACIN | Ki | > | 10000.0 | nM | - |