Assay Detail
Binding
CHEMBL1815532
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Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.95 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL78755 | — | — | 1 | 7.92 |
| CHEMBL187901 | — | — | 1 | 7.89 |
| CHEMBL187274 | — | — | 1 | 7.68 |
| CHEMBL190024 | — | — | 1 | 7.54 |
| CHEMBL189526 | — | — | 1 | 7.50 |
| CHEMBL190733 | — | — | 1 | 7.48 |
| CHEMBL1738787 | — | — | 1 | 7.43 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL1738792 | — | — | 1 | 7.39 |
| CHEMBL366069 | — | — | 1 | 6.97 |
| CHEMBL1813211 | — | — | 1 | 6.92 |
| CHEMBL1813215 | — | — | 1 | 6.59 |
| CHEMBL191045 | — | — | 1 | 6.46 |
| CHEMBL1813212 | — | — | 1 | 6.45 |
| CHEMBL1813208 | — | — | 1 | 6.43 |
| CHEMBL1813217 | — | — | 1 | 6.43 |
| CHEMBL1813206 | — | — | 1 | 6.42 |
| CHEMBL1813218 | — | — | 1 | 6.39 |
| CHEMBL1813210 | — | — | 1 | 6.38 |
| CHEMBL1813214 | — | — | 1 | 6.36 |
| CHEMBL1813207 | — | — | 1 | 6.36 |
| CHEMBL1813213 | — | — | 1 | 6.34 |
| CHEMBL1813216 | — | — | 1 | 6.32 |
| CHEMBL1813219 | — | — | 1 | 6.29 |
| CHEMBL1813209 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL78755 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL187901 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL187274 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL190024 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL189526 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL190733 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL1738787 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1738792 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL366069 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL1813211 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL1813215 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL191045 | — | Ki | = | 351.0 | nM | 6.46 |
| CHEMBL1813212 | — | Ki | = | 356.0 | nM | 6.45 |
| CHEMBL1813208 | — | Ki | = | 368.0 | nM | 6.43 |
| CHEMBL1813217 | — | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL1813206 | — | Ki | = | 376.0 | nM | 6.42 |
| CHEMBL1813218 | — | Ki | = | 409.0 | nM | 6.39 |
| CHEMBL1813210 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL1813214 | — | Ki | = | 435.0 | nM | 6.36 |
| CHEMBL1813207 | — | Ki | = | 435.0 | nM | 6.36 |
| CHEMBL1813213 | — | Ki | = | 453.0 | nM | 6.34 |
| CHEMBL1813216 | — | Ki | = | 475.0 | nM | 6.32 |
| CHEMBL1813219 | — | Ki | = | 517.0 | nM | 6.29 |
| CHEMBL1813209 | — | Ki | = | 561.0 | nM | 6.25 |