Assay Detail
Binding
CHEMBL1815535
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Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.82 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1813208 | — | — | 1 | 9.04 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.60 |
| CHEMBL1738787 | — | — | 1 | 8.42 |
| CHEMBL78755 | — | — | 1 | 8.39 |
| CHEMBL1738792 | — | — | 1 | 8.19 |
| CHEMBL1813207 | — | — | 1 | 8.15 |
| CHEMBL1813206 | — | — | 1 | 8.14 |
| CHEMBL1813210 | — | — | 1 | 8.13 |
| CHEMBL1813219 | — | — | 1 | 8.12 |
| CHEMBL1813218 | — | — | 1 | 8.06 |
| CHEMBL1813214 | — | — | 1 | 8.05 |
| CHEMBL1813213 | — | — | 1 | 8.04 |
| CHEMBL191045 | — | — | 1 | 8.03 |
| CHEMBL1813209 | — | — | 1 | 8.00 |
| CHEMBL189526 | — | — | 1 | 7.98 |
| CHEMBL187274 | — | — | 1 | 7.81 |
| CHEMBL1813215 | — | — | 1 | 7.77 |
| CHEMBL190024 | — | — | 1 | 7.75 |
| CHEMBL190733 | — | — | 1 | 7.63 |
| CHEMBL187901 | — | — | 1 | 7.62 |
| CHEMBL1813211 | — | — | 1 | 7.56 |
| CHEMBL366069 | — | — | 1 | 7.46 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.39 |
| CHEMBL1813216 | — | — | 1 | 7.14 |
| CHEMBL1813217 | — | — | 1 | 7.11 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.46 |
| CHEMBL1813212 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1813208 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1738787 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL78755 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL1738792 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL1813207 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL1813206 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL1813210 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL1813219 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL1813218 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL1813214 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL1813213 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL191045 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL1813209 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL189526 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL187274 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL1813215 | — | Ki | = | 16.9 | nM | 7.77 |
| CHEMBL190024 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL190733 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL187901 | — | Ki | = | 24.1 | nM | 7.62 |
| CHEMBL1813211 | — | Ki | = | 27.7 | nM | 7.56 |
| CHEMBL366069 | — | Ki | = | 34.3 | nM | 7.46 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL1813216 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL1813217 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL1813212 | — | Ki | = | 583.0 | nM | 6.23 |