Assay Detail
Functional
CHEMBL1815755
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human H460 cells assessed as stimulation of topoisomerase 1-mediated DNA cleavage
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.80 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1813809 | — | — | 1 | 6.40 |
| CHEMBL1813808 | — | — | 1 | 6.40 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 5.86 |
| CHEMBL400146 | TOPOPYRONE C | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1813809 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1813808 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL400146 | TOPOPYRONE C | IC50 | = | 29500.0 | nM | 4.53 |