Assay Detail
Functional
CHEMBL1815918
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Antiangiogenesis activity in HUVEC assessed as inhibition of VEGF-induced cell proliferation after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemical constituents of a marine fungus, Arthrinium sacchari.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.15 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494856 | CYTOCHALASIN E | — | 1 | 7.94 |
| CHEMBL1812033 | DECARBOXYHYDROXYCITRINONE | — | 1 | 5.12 |
| CHEMBL516554 | MYROCIN A | — | 1 | 4.96 |
| CHEMBL1812034 | LIBERTELLENONE C | — | 1 | 4.53 |
| CHEMBL1812032 | LIBERTELLENONE F | — | 1 | 4.19 |
| CHEMBL1812030 | MYROCIN D | — | 1 | 4.15 |
| CHEMBL1812031 | LIBERTELLENONE E | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494856 | CYTOCHALASIN E | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL1812033 | DECARBOXYHYDROXYCITRINONE | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL516554 | MYROCIN A | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1812034 | LIBERTELLENONE C | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL1812032 | LIBERTELLENONE F | IC50 | = | 64100.0 | nM | 4.19 |
| CHEMBL1812030 | MYROCIN D | IC50 | = | 70800.0 | nM | 4.15 |
| CHEMBL1812031 | LIBERTELLENONE E | IC50 | = | 236400.0 | nM | - |