Assay Detail
Binding
CHEMBL1815993
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Inhibition of Salmonella Typhimurium recombinant carbonic anhydrase 1 at pH 8.3 by stopped flow CO2 hydration assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 5.80 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71611 | — | — | 1 | 7.29 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.23 |
| CHEMBL268439 | — | — | 1 | 7.17 |
| CHEMBL7146 | — | — | 1 | 7.14 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 7.07 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.05 |
| CHEMBL266026 | — | — | 1 | 7.04 |
| CHEMBL51668 | — | — | 1 | 6.91 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.87 |
| CHEMBL6633 | — | — | 1 | 6.61 |
| CHEMBL360356 | — | — | 1 | 6.37 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 6.35 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.28 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.21 |
| CHEMBL6685 | — | — | 1 | 6.19 |
| CHEMBL6753 | — | — | 1 | 6.17 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.16 |
| CHEMBL265674 | — | — | 1 | 6.11 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 5.26 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 5.25 |
| CHEMBL6705 | — | — | 1 | 5.25 |
| CHEMBL6784 | — | — | 1 | 5.24 |
| CHEMBL7087 | — | — | 1 | 5.23 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.23 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 5.22 |
| CHEMBL7204 | — | — | 1 | 5.21 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 5.19 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 5.19 |
| CHEMBL6853 | — | — | 1 | 5.18 |
| CHEMBL6919 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71611 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL268439 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL7146 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL266026 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL51668 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL6633 | — | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL360356 | — | Ki | = | 424.0 | nM | 6.37 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 445.0 | nM | 6.35 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 528.0 | nM | 6.28 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 624.0 | nM | 6.21 |
| CHEMBL6685 | — | Ki | = | 642.0 | nM | 6.19 |
| CHEMBL6753 | — | Ki | = | 671.0 | nM | 6.17 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 687.0 | nM | 6.16 |
| CHEMBL265674 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 5430.0 | nM | 5.26 |
| CHEMBL26 | SULPIRIDE | Ki | = | 5640.0 | nM | 5.25 |
| CHEMBL6705 | — | Ki | = | 5580.0 | nM | 5.25 |
| CHEMBL6784 | — | Ki | = | 5750.0 | nM | 5.24 |
| CHEMBL118 | CELECOXIB | Ki | = | 5830.0 | nM | 5.23 |
| CHEMBL7087 | — | Ki | = | 5930.0 | nM | 5.23 |
| CHEMBL414 | CARZENIDE | Ki | = | 6010.0 | nM | 5.22 |
| CHEMBL7204 | — | Ki | = | 6140.0 | nM | 5.21 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 6510.0 | nM | 5.19 |
| CHEMBL419 | MAFENIDE | Ki | = | 6450.0 | nM | 5.19 |
| CHEMBL6853 | — | Ki | = | 6550.0 | nM | 5.18 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 6810.0 | nM | 5.17 |
| CHEMBL328560 | SULTHIAME | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 6790.0 | nM | 5.17 |
| CHEMBL6919 | — | Ki | = | 6820.0 | nM | 5.17 |
| CHEMBL67755 | — | Ki | = | 6910.0 | nM | 5.16 |
| CHEMBL77517 | INDISULAM | Ki | = | 6860.0 | nM | 5.16 |
| CHEMBL865 | VALDECOXIB | Ki | = | 6850.0 | nM | 5.16 |
| CHEMBL306195 | — | Ki | = | 7060.0 | nM | 5.15 |
| CHEMBL266240 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 9380.0 | nM | 5.03 |
| CHEMBL7092 | — | Ki | = | 9550.0 | nM | 5.02 |
| CHEMBL176495 | — | Ki | = | 12100.0 | nM | 4.92 |
| CHEMBL310671 | SACCHARIN | Ki | = | 26700.0 | nM | 4.57 |