Assay Detail
Functional
CHEMBL1816010
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Antagonist activity at Escherichia coli DH5alpha (pJN105L + pSC11) LasR assessed as inhibition of OdDHL-induced quorum sensing activation after 8 hrs by beta-galactosidase reporter gene assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli DH5[alpha] |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Thiolactone modulators of quorum sensing revealed through library design and screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.94 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1812080 | — | — | 1 | 6.85 |
| CHEMBL1812087 | — | — | 1 | 6.40 |
| CHEMBL1814832 | — | — | 1 | 6.10 |
| CHEMBL1814831 | — | — | 1 | 5.96 |
| CHEMBL1812082 | — | — | 1 | 5.60 |
| CHEMBL1812089 | — | — | 1 | 5.54 |
| CHEMBL1812086 | — | — | 1 | 5.14 |
| CHEMBL1823930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1812080 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1812087 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1814832 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL1814831 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1812082 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1812089 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1812086 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1823930 | — | IC50 | - | — | - |