Assay Detail
Functional
CHEMBL1816085
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Antiproliferative activity against human A549 cells expressing EGFR assessed as inhibition of basal cell growth after 48 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The combination of 4-anilinoquinazoline and cinnamic acid: a novel mode of binding to the epidermal growth factor receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.75 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.57 |
| CHEMBL1812572 | — | — | 1 | 6.48 |
| CHEMBL1812573 | — | — | 1 | 6.31 |
| CHEMBL1812571 | — | — | 1 | 6.12 |
| CHEMBL1812560 | — | — | 1 | 6.01 |
| CHEMBL1812559 | — | — | 1 | 5.87 |
| CHEMBL1812570 | — | — | 1 | 5.67 |
| CHEMBL52765 | — | — | 1 | 4.38 |
| CHEMBL343352 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1812572 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1812573 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1812571 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1812560 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL1812559 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL1812570 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL52765 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL343352 | — | IC50 | = | 47000.0 | nM | 4.33 |