Assay Detail
Functional
CHEMBL1816253
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Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.94 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.72 |
| CHEMBL1811985 | — | — | 1 | 5.39 |
| CHEMBL1811988 | — | — | 1 | 5.38 |
| CHEMBL596242 | — | — | 1 | 5.22 |
| CHEMBL586902 | — | — | 1 | 5.20 |
| CHEMBL1811976 | — | — | 1 | 5.13 |
| CHEMBL1811981 | — | — | 1 | 5.06 |
| CHEMBL1811978 | — | — | 1 | 5.02 |
| CHEMBL1811982 | — | — | 1 | 4.99 |
| CHEMBL1811986 | — | — | 1 | 4.97 |
| CHEMBL1811980 | — | — | 1 | 4.96 |
| CHEMBL1811979 | — | — | 1 | 4.94 |
| CHEMBL1811973 | — | — | 1 | 4.83 |
| CHEMBL1811977 | — | — | 1 | 4.78 |
| CHEMBL1811975 | — | — | 1 | 4.55 |
| CHEMBL1811984 | — | — | 1 | 4.52 |
| CHEMBL1811987 | — | — | 1 | 4.49 |
| CHEMBL1811972 | — | — | 1 | 4.43 |
| CHEMBL1811983 | — | — | 1 | 4.34 |
| CHEMBL1271378 | — | — | 1 | - |
| CHEMBL1811974 | — | — | 1 | - |
| CHEMBL1811921 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1811985 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1811988 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL596242 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL586902 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1811976 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1811981 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1811978 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL1811982 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL1811986 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL1811980 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1811979 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1811973 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL1811977 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL1811975 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL1811984 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL1811987 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL1811972 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL1811983 | — | IC50 | = | 46100.0 | nM | 4.34 |
| CHEMBL1271378 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1811974 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1811921 | — | IC50 | > | 50000.0 | nM | - |