Assay Detail
Binding
CHEMBL1816571
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Inhibition of human recombinant MAOA expressed in insect cells using kynuramine substrate using Cheng and Prusoff equation by fluorescence spectroscopy
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of monoamine oxidase by C5-substituted phthalimide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.31 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1813523 | — | — | 1 | 7.24 |
| CHEMBL1813522 | — | — | 1 | 6.70 |
| CHEMBL1813524 | — | — | 1 | 6.54 |
| CHEMBL1813525 | — | — | 1 | 6.54 |
| CHEMBL1813520 | — | — | 1 | 6.34 |
| CHEMBL1813519 | — | — | 1 | 6.03 |
| CHEMBL342357 | — | — | 1 | 5.96 |
| CHEMBL1813518 | — | — | 1 | 5.81 |
| CHEMBL1813521 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1813523 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL1813522 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL1813524 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL1813525 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL1813520 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL1813519 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL342357 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1813518 | — | Ki | = | 1540.0 | nM | 5.81 |
| CHEMBL1813521 | — | Ki | = | 2370.0 | nM | 5.62 |