Assay Detail
Binding
CHEMBL1816618
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; GABA-A site (alpha1/beta2 interface) (CHEMBL1907597) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 4.76 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814294 | — | — | 1 | 5.70 |
| CHEMBL1814312 | — | — | 1 | 5.42 |
| CHEMBL1814310 | — | — | 1 | 5.11 |
| CHEMBL1814290 | — | — | 1 | 5.08 |
| CHEMBL1814307 | — | — | 1 | 5.04 |
| CHEMBL1814308 | — | — | 1 | 5.03 |
| CHEMBL1814306 | — | — | 1 | 4.91 |
| CHEMBL555297 | — | — | 1 | 4.90 |
| CHEMBL1829020 | — | — | 1 | 4.84 |
| CHEMBL1829021 | — | — | 1 | 4.83 |
| CHEMBL1814289 | — | — | 1 | 4.77 |
| CHEMBL1814309 | — | — | 1 | 4.73 |
| CHEMBL557713 | — | — | 1 | 4.71 |
| CHEMBL1814300 | — | — | 1 | 4.66 |
| CHEMBL231391 | — | — | 1 | 4.62 |
| CHEMBL1814305 | — | — | 1 | 4.60 |
| CHEMBL89700 | METHYLHONOKIOL | — | 1 | 4.57 |
| CHEMBL1814291 | — | — | 1 | 4.47 |
| CHEMBL182529 | — | — | 1 | 4.45 |
| CHEMBL180920 | MAGNOLOL | — | 1 | 4.43 |
| CHEMBL16901 | HONOKIOL | — | 1 | 4.41 |
| CHEMBL89828 | — | — | 1 | 4.38 |
| CHEMBL1814295 | — | — | 1 | 4.26 |
| CHEMBL1829017 | — | — | 1 | 4.22 |
| CHEMBL1829023 | — | — | 1 | - |
| CHEMBL1829024 | — | — | 1 | - |
| CHEMBL1814302 | — | — | 1 | - |
| CHEMBL1814303 | — | — | 1 | - |
| CHEMBL1814293 | — | — | 1 | - |
| CHEMBL1814304 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814294 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1814312 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1814310 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1814290 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1814307 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1814308 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1814306 | — | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL555297 | — | EC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL1829020 | — | EC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL1829021 | — | EC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL1814289 | — | EC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL1814309 | — | EC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL557713 | — | EC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL1814300 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL231391 | — | EC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL1814305 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL89700 | METHYLHONOKIOL | EC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL1814291 | — | EC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL182529 | — | EC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL180920 | MAGNOLOL | EC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL16901 | HONOKIOL | EC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL89828 | — | EC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL1814295 | — | EC50 | = | 54300.0 | nM | 4.26 |
| CHEMBL1829017 | — | EC50 | = | 59900.0 | nM | 4.22 |
| CHEMBL1829023 | — | EC50 | - | — | - | |
| CHEMBL1829024 | — | EC50 | - | — | - | |
| CHEMBL1814302 | — | EC50 | - | — | - | |
| CHEMBL1814303 | — | EC50 | - | — | - | |
| CHEMBL1814293 | — | EC50 | = | 105400.0 | nM | - |
| CHEMBL1814304 | — | EC50 | - | — | - | |
| CHEMBL1814311 | — | EC50 | - | — | - | |
| CHEMBL1814292 | — | EC50 | - | — | - |