Assay Detail
Binding
CHEMBL1816623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of GABA Aalpha2beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2 (CHEMBL3885571) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.98 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814307 | — | — | 1 | 5.50 |
| CHEMBL1814312 | — | — | 1 | 5.10 |
| CHEMBL16901 | HONOKIOL | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814307 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1814312 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL16901 | HONOKIOL | EC50 | = | 46400.0 | nM | 4.33 |