Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1816636

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human K562 cells after 48 hrs by hemocytometer
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type K562
Confidence 1 — Organism
Curated By Autocuration

Target

K562 (CHEMBL385)
Type CELL-LINE
Organism Homo sapiens

Publication

Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Günther EG, Unger E.
Bioorg Med Chem (2011) 19 : 4183 -4191
PubMed 21705223 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.34 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL378544 VINBLASTINE SULFATE 4.0 1 9.00
CHEMBL53463 DOXORUBICIN 4.0 1 8.00
CHEMBL107 COLCHICINE 4.0 1 7.70
CHEMBL116173 1 7.70
CHEMBL1814615 1 6.96
CHEMBL1814612 1 6.89
CHEMBL1814614 1 6.28
CHEMBL1814606 1 6.17
CHEMBL1814608 1 6.14
CHEMBL1814610 1 6.06
CHEMBL1814613 1 5.57
CHEMBL1814620 1 5.56
CHEMBL1814609 1 5.47
CHEMBL1814605 1 5.17
CHEMBL1814617 1 5.08
CHEMBL1814618 1 5.05
CHEMBL1814607 1 5.03
CHEMBL1814619 1 -
CHEMBL9514 NOCODAZOLE 2.0 1 -
CHEMBL61 PODOFILOX 4.0 1 -
CHEMBL1814616 1 -
CHEMBL1814611 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL378544 VINBLASTINE SULFATE IC50 = 1.0 nM 9.00
CHEMBL53463 DOXORUBICIN IC50 = 10.0 nM 8.00
CHEMBL107 COLCHICINE IC50 = 20.0 nM 7.70
CHEMBL116173 IC50 = 20.0 nM 7.70
CHEMBL1814615 IC50 = 110.0 nM 6.96
CHEMBL1814612 IC50 = 130.0 nM 6.89
CHEMBL1814614 IC50 = 520.0 nM 6.28
CHEMBL1814606 IC50 = 680.0 nM 6.17
CHEMBL1814608 IC50 = 730.0 nM 6.14
CHEMBL1814610 IC50 = 870.0 nM 6.06
CHEMBL1814613 IC50 = 2670.0 nM 5.57
CHEMBL1814620 IC50 = 2740.0 nM 5.56
CHEMBL1814609 IC50 = 3400.0 nM 5.47
CHEMBL1814605 IC50 = 6800.0 nM 5.17
CHEMBL1814617 IC50 = 8410.0 nM 5.08
CHEMBL1814618 IC50 = 9000.0 nM 5.05
CHEMBL1814607 IC50 = 9300.0 nM 5.03
CHEMBL1814619 IC50 > 80000.0 nM -
CHEMBL9514 NOCODAZOLE IC50 - -
CHEMBL61 PODOFILOX IC50 - -
CHEMBL1814616 IC50 - -
CHEMBL1814611 IC50 > 30000.0 nM -