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Assay Detail

CHEMBL1816668

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Hepatitis C virus genotype 1b infected in human Huh-7.5.1 cells after 48 to 72 hrs by luciferase reporter assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication.
Valiaeva N, Wyles DL, Schooley RT, Hwu JB, Beadle JR, Prichard MN, Hostetler KY.
Bioorg Med Chem (2011) 19 : 4616 -4625
PubMed 21719300 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 4.98 5.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1812223 1 5.84
CHEMBL382196 1 5.81
CHEMBL1812225 1 5.63
CHEMBL1812224 1 5.33
CHEMBL1812226 1 5.12
CHEMBL1812320 1 5.08
CHEMBL1812325 1 5.05
CHEMBL1812321 1 4.90
CHEMBL1812326 1 4.74
CHEMBL1812319 1 4.74
CHEMBL1812228 1 4.70
CHEMBL1812318 1 4.67
CHEMBL1812322 1 4.66
CHEMBL1812317 1 4.59
CHEMBL1812323 1 4.59
CHEMBL1812227 1 4.29
CHEMBL1812324 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1812223 EC50 = 1430.0 nM 5.84
CHEMBL382196 EC50 = 1550.0 nM 5.81
CHEMBL1812225 EC50 = 2360.0 nM 5.63
CHEMBL1812224 EC50 = 4650.0 nM 5.33
CHEMBL1812226 EC50 = 7590.0 nM 5.12
CHEMBL1812320 EC50 = 8260.0 nM 5.08
CHEMBL1812325 EC50 = 8900.0 nM 5.05
CHEMBL1812321 EC50 = 12600.0 nM 4.90
CHEMBL1812326 EC50 = 18100.0 nM 4.74
CHEMBL1812319 EC50 = 18200.0 nM 4.74
CHEMBL1812228 EC50 = 20100.0 nM 4.70
CHEMBL1812318 EC50 = 21300.0 nM 4.67
CHEMBL1812322 EC50 = 22000.0 nM 4.66
CHEMBL1812317 EC50 = 25600.0 nM 4.59
CHEMBL1812323 EC50 = 25500.0 nM 4.59
CHEMBL1812227 EC50 = 51200.0 nM 4.29
CHEMBL1812324 EC50 > 150000.0 nM -