Assay Detail
Functional
CHEMBL1816698
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Antiproliferative activity against human NCI-H460 cells after 1 hr by coulter counter analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.03 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373114 | LAMELLARIN D | — | 1 | 7.18 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 5.76 |
| CHEMBL1813934 | — | — | 1 | 5.40 |
| CHEMBL1813929 | — | — | 1 | 4.22 |
| CHEMBL1813931 | — | — | 1 | 4.22 |
| CHEMBL1813932 | — | — | 1 | 4.22 |
| CHEMBL1813933 | — | — | 1 | 4.22 |
| CHEMBL1813928 | — | — | 1 | - |
| CHEMBL1813930 | — | — | 1 | - |
| CHEMBL1813935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373114 | LAMELLARIN D | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL1813934 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL1813929 | — | IC50 | = | 60800.0 | nM | 4.22 |
| CHEMBL1813931 | — | IC50 | = | 60800.0 | nM | 4.22 |
| CHEMBL1813932 | — | IC50 | = | 60800.0 | nM | 4.22 |
| CHEMBL1813933 | — | IC50 | = | 60800.0 | nM | 4.22 |
| CHEMBL1813928 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL1813930 | — | IC50 | = | 118800.0 | nM | - |
| CHEMBL1813935 | — | IC50 | = | 117500.0 | nM | - |