Assay Detail
Functional
CHEMBL1816699
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Antiproliferative activity against human NCI-H460 cells after 72 hrs by coulter counter analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.59 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373114 | LAMELLARIN D | — | 1 | 8.52 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.80 |
| CHEMBL1813934 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373114 | LAMELLARIN D | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1813934 | — | IC50 | = | 350.0 | nM | 6.46 |