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Assay Detail

CHEMBL1816735

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Functional
Antileishmanial activity against beta-lactamase transfected Leishmania amazonensis promastigotes infected in macrophages after 72 hrs by spectrophotometric analysis
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania amazonensis
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania amazonensis (CHEMBL612877)
Type ORGANISM
Organism Leishmania amazonensis

Publication

Molecular factors governing inhibition of arylimidamides against Leishmania: conservative computational modeling to improve chemotherapies.
Collar CJ, Zhu X, Werbovetz K, Boykin DW, Wilson WD.
Bioorg Med Chem (2011) 19 : 4552 -4561
PubMed 21741248 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 55 6.30 7.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1814124 1 7.35
CHEMBL1275764 1 7.06
CHEMBL1814130 1 7.02
CHEMBL1814110 1 6.96
CHEMBL450746 1 6.96
CHEMBL1276549 1 6.92
CHEMBL1814125 1 6.89
CHEMBL49894 1 6.80
CHEMBL1814115 1 6.77
CHEMBL1814113 1 6.77
CHEMBL1814116 1 6.68
CHEMBL1814139 1 6.66
CHEMBL1814122 1 6.60
CHEMBL1814131 1 6.57
CHEMBL416108 1 6.54
CHEMBL1814142 1 6.52
CHEMBL1814145 1 6.50
CHEMBL49128 1 6.43
CHEMBL1813916 1 6.43
CHEMBL1814135 1 6.31
CHEMBL1813921 1 6.29
CHEMBL52210 1 6.28
CHEMBL48856 1 6.25
CHEMBL1814123 1 6.23
CHEMBL1813922 1 6.21
CHEMBL1814140 1 6.19
CHEMBL1814111 1 6.16
CHEMBL1813915 1 6.13
CHEMBL1814141 1 6.09
CHEMBL1814118 1 6.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1814124 IC50 = 45.0 nM 7.35
CHEMBL1275764 IC50 = 87.0 nM 7.06
CHEMBL1814130 IC50 = 95.0 nM 7.02
CHEMBL1814110 IC50 = 110.0 nM 6.96
CHEMBL450746 IC50 = 110.0 nM 6.96
CHEMBL1276549 IC50 = 120.0 nM 6.92
CHEMBL1814125 IC50 = 130.0 nM 6.89
CHEMBL49894 IC50 = 160.0 nM 6.80
CHEMBL1814115 IC50 = 170.0 nM 6.77
CHEMBL1814113 IC50 = 170.0 nM 6.77
CHEMBL1814116 IC50 = 210.0 nM 6.68
CHEMBL1814139 IC50 = 220.0 nM 6.66
CHEMBL1814122 IC50 = 250.0 nM 6.60
CHEMBL1814131 IC50 = 270.0 nM 6.57
CHEMBL416108 IC50 = 290.0 nM 6.54
CHEMBL1814142 IC50 = 300.0 nM 6.52
CHEMBL1814145 IC50 = 320.0 nM 6.50
CHEMBL49128 IC50 = 370.0 nM 6.43
CHEMBL1813916 IC50 = 370.0 nM 6.43
CHEMBL1814135 IC50 = 490.0 nM 6.31
CHEMBL1813921 IC50 = 510.0 nM 6.29
CHEMBL52210 IC50 = 530.0 nM 6.28
CHEMBL48856 IC50 = 560.0 nM 6.25
CHEMBL1814123 IC50 = 590.0 nM 6.23
CHEMBL1813922 IC50 = 620.0 nM 6.21
CHEMBL1814140 IC50 = 640.0 nM 6.19
CHEMBL1814111 IC50 = 700.0 nM 6.16
CHEMBL1813915 IC50 = 740.0 nM 6.13
CHEMBL1814141 IC50 = 810.0 nM 6.09
CHEMBL1814118 IC50 = 900.0 nM 6.05
CHEMBL1813920 IC50 = 960.0 nM 6.02
CHEMBL1814137 IC50 = 1100.0 nM 5.96
CHEMBL1813914 IC50 = 1400.0 nM 5.85
CHEMBL1814138 IC50 = 1700.0 nM 5.77
CHEMBL1814127 IC50 = 2100.0 nM 5.68
CHEMBL1814132 IC50 = 2700.0 nM 5.57
CHEMBL1813913 IC50 = 3100.0 nM 5.51
CHEMBL1814117 IC50 = 3700.0 nM 5.43
CHEMBL1814136 IC50 = 4700.0 nM 5.33
CHEMBL1814112 IC50 = 5000.0 nM 5.30
CHEMBL1813919 IC50 = 5500.0 nM 5.26
CHEMBL1813918 IC50 > 10000.0 nM -
CHEMBL1814133 IC50 > 10000.0 nM -
CHEMBL1814134 IC50 > 10000.0 nM -
CHEMBL1813917 IC50 > 10000.0 nM -
CHEMBL1814129 IC50 > 10000.0 nM -
CHEMBL1814128 IC50 > 10000.0 nM -
CHEMBL1614813 IC50 > 10000.0 nM -
CHEMBL1814126 IC50 > 10000.0 nM -
CHEMBL1814121 IC50 > 10000.0 nM -