Assay Detail
Binding
CHEMBL1816907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine testes DPP9 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.02 | 7.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814739 | — | — | 1 | 7.59 |
| CHEMBL1814740 | — | — | 1 | 7.57 |
| CHEMBL1814741 | — | — | 1 | 7.30 |
| CHEMBL1814753 | — | — | 1 | 7.19 |
| CHEMBL1814633 | — | — | 1 | 7.08 |
| CHEMBL3216066 | — | — | 1 | 6.65 |
| CHEMBL1814747 | — | — | 1 | 6.62 |
| CHEMBL1814745 | — | — | 1 | 6.58 |
| CHEMBL1814748 | — | — | 1 | 6.58 |
| CHEMBL1814743 | — | — | 1 | 6.28 |
| CHEMBL1814749 | — | — | 1 | 6.27 |
| CHEMBL1811949 | — | — | 1 | 6.27 |
| CHEMBL1814751 | — | — | 1 | 6.20 |
| CHEMBL1814752 | — | — | 1 | 6.17 |
| CHEMBL3215830 | — | — | 1 | 5.95 |
| CHEMBL1814756 | — | — | 1 | 5.85 |
| CHEMBL1814755 | — | — | 1 | 5.77 |
| CHEMBL1814760 | — | — | 1 | 5.68 |
| CHEMBL3216276 | — | — | 1 | 5.58 |
| CHEMBL1814634 | — | — | 1 | 5.40 |
| CHEMBL1814737 | — | — | 1 | 5.30 |
| CHEMBL1814759 | — | — | 1 | 4.79 |
| CHEMBL1814754 | — | — | 1 | 4.65 |
| CHEMBL1814757 | — | — | 1 | 4.54 |
| CHEMBL1814758 | — | — | 1 | 4.46 |
| CHEMBL1814744 | — | — | 1 | 4.27 |
| CHEMBL1814738 | — | — | 1 | - |
| CHEMBL1814632 | — | — | 1 | - |
| CHEMBL3216065 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814739 | — | IC50 | = | 25.4 | nM | 7.59 |
| CHEMBL1814740 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL1814741 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1814753 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1814633 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3216066 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL1814747 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1814745 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1814748 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1814743 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1814749 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1811949 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1814751 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1814752 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL3215830 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL1814756 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1814755 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1814760 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3216276 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1814634 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1814737 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1814759 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL1814754 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL1814757 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL1814758 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1814744 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL1814738 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1814632 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3216065 | — | IC50 | > | 50000.0 | nM | - |