Assay Detail
Binding
CHEMBL1817010
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Inhibition of human recombinant MAOA assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline by fluorimetry
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.79 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823805 | — | — | 1 | 6.28 |
| CHEMBL363555 | — | — | 1 | 5.98 |
| CHEMBL1222281 | — | — | 1 | 5.46 |
| CHEMBL1222280 | — | — | 1 | 5.16 |
| CHEMBL1814645 | — | — | 1 | 4.98 |
| CHEMBL1823812 | — | — | 1 | 4.89 |
| CHEMBL1823813 | — | — | 1 | 4.66 |
| CHEMBL1823802 | — | — | 1 | 4.58 |
| CHEMBL255822 | — | — | 1 | 4.54 |
| CHEMBL1222279 | — | — | 1 | 4.53 |
| CHEMBL1823815 | — | — | 1 | 4.45 |
| CHEMBL1823814 | — | — | 1 | 4.45 |
| CHEMBL1814648 | — | — | 1 | 4.43 |
| CHEMBL1814644 | — | — | 1 | 4.40 |
| CHEMBL1823803 | — | — | 1 | 4.30 |
| CHEMBL1823807 | — | — | 1 | 4.17 |
| CHEMBL1823810 | — | — | 1 | 4.15 |
| CHEMBL1823811 | — | — | 1 | - |
| CHEMBL1823808 | — | — | 1 | - |
| CHEMBL1814646 | — | — | 1 | - |
| CHEMBL1814647 | — | — | 1 | - |
| CHEMBL568150 | — | — | 1 | - |
| CHEMBL1061 | GLITAZONE | — | 1 | - |
| CHEMBL1821748 | — | — | 1 | - |
| CHEMBL602048 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823805 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL363555 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1222281 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL1222280 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL1814645 | — | IC50 | = | 10580.0 | nM | 4.98 |
| CHEMBL1823812 | — | IC50 | = | 12970.0 | nM | 4.89 |
| CHEMBL1823813 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL1823802 | — | IC50 | = | 26230.0 | nM | 4.58 |
| CHEMBL255822 | — | IC50 | = | 28550.0 | nM | 4.54 |
| CHEMBL1222279 | — | IC50 | = | 29850.0 | nM | 4.53 |
| CHEMBL1823815 | — | IC50 | = | 35260.0 | nM | 4.45 |
| CHEMBL1823814 | — | IC50 | = | 35260.0 | nM | 4.45 |
| CHEMBL1814648 | — | IC50 | = | 37260.0 | nM | 4.43 |
| CHEMBL1814644 | — | IC50 | = | 39890.0 | nM | 4.40 |
| CHEMBL1823803 | — | IC50 | = | 50510.0 | nM | 4.30 |
| CHEMBL1823807 | — | IC50 | = | 67310.0 | nM | 4.17 |
| CHEMBL1823810 | — | IC50 | = | 70500.0 | nM | 4.15 |
| CHEMBL1823811 | — | IC50 | - | — | - | |
| CHEMBL1823808 | — | IC50 | = | 380100.0 | nM | - |
| CHEMBL1814646 | — | IC50 | = | 252400.0 | nM | - |
| CHEMBL1814647 | — | IC50 | - | — | - | |
| CHEMBL568150 | — | IC50 | = | 165800.0 | nM | - |
| CHEMBL1061 | GLITAZONE | IC50 | = | 193600.0 | nM | - |
| CHEMBL1821748 | — | IC50 | = | 398800.0 | nM | - |
| CHEMBL602048 | — | IC50 | - | — | - |