Assay Detail
Binding
CHEMBL1817023
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human platelet-type N-terminally His6-tagged 12-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by UV-vis spectrophotometer analysis
38
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX12 (CHEMBL3687) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.75 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1405150 | — | — | 3 | 6.42 |
| CHEMBL1573436 | — | — | 3 | 6.37 |
| CHEMBL1369893 | — | — | 1 | 6.10 |
| CHEMBL528045 | — | — | 1 | 6.00 |
| CHEMBL580727 | — | — | 1 | 6.00 |
| CHEMBL1531895 | — | — | 1 | 5.92 |
| CHEMBL1532739 | — | — | 1 | 5.92 |
| CHEMBL1487619 | — | — | 1 | 5.80 |
| CHEMBL1200596 | CHLOROXINE | 4.0 | 1 | 5.72 |
| CHEMBL1561166 | — | — | 1 | 5.70 |
| CHEMBL1609517 | — | — | 1 | 5.70 |
| CHEMBL1394624 | — | — | 1 | 5.70 |
| CHEMBL1572233 | — | — | 1 | 5.58 |
| CHEMBL1521956 | — | — | 1 | 5.52 |
| CHEMBL1406616 | — | — | 1 | 5.52 |
| CHEMBL1813492 | — | — | 1 | 5.52 |
| CHEMBL1370513 | — | — | 1 | 5.47 |
| CHEMBL1476391 | — | — | 1 | 5.46 |
| CHEMBL1512403 | — | — | 1 | 5.30 |
| CHEMBL1512078 | — | — | 1 | 4.85 |
| CHEMBL1323844 | — | — | 1 | - |
| CHEMBL1370315 | — | — | 1 | - |
| CHEMBL1437477 | — | — | 1 | - |
| CHEMBL1555876 | — | — | 1 | - |
| CHEMBL1410433 | — | — | 1 | - |
| CHEMBL1319062 | — | — | 1 | - |
| CHEMBL1448145 | — | — | 1 | - |
| CHEMBL1593604 | — | — | 1 | - |
| CHEMBL1323467 | — | — | 1 | - |
| CHEMBL1593083 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1405150 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1573436 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1369893 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1405150 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL528045 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1573436 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL580727 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1532739 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1531895 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1487619 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1200596 | CHLOROXINE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1561166 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1394624 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1609517 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1572233 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1406616 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1521956 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1813492 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1370513 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1476391 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1512403 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1512078 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1555876 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1405150 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1323844 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL1573436 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1370315 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL1437477 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL1528315 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL1528943 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL1705387 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1813491 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1593083 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1323467 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL1593604 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL1448145 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL1319062 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL1410433 | — | IC50 | > | 75000.0 | nM | - |