Assay Detail
Binding
CHEMBL1817024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 5-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by UV-vis spectrophotometer analysis
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.44 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200596 | CHLOROXINE | 4.0 | 1 | 5.44 |
| CHEMBL1369893 | — | — | 1 | - |
| CHEMBL528045 | — | — | 1 | - |
| CHEMBL1573436 | — | — | 2 | - |
| CHEMBL1370513 | — | — | 1 | - |
| CHEMBL580727 | — | — | 1 | - |
| CHEMBL1405150 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200596 | CHLOROXINE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1369893 | — | IC50 | - | — | - | |
| CHEMBL528045 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1573436 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1370513 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL580727 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1573436 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1405150 | — | IC50 | > | 100000.0 | nM | - |