Assay Detail
Binding
CHEMBL1817033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse N-terminally His6-tagged 12-lipoxygenase expressed in SF9 insect cells assessed as 12-HPETE formation using arachidonic acid by UV-vis spectrophotometer analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX12 (CHEMBL3225) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.85 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1573436 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1573436 | — | IC50 | = | 14000.0 | nM | 4.85 |