Assay Detail
Binding
CHEMBL1817162
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Inhibition of HCV genotype 1b J4 N-terminal His-tagged NS5Bdelta21 polymerase expressed in Escherichia coli C41(DE3) assessed as amount of double-stranded RNA synthesis
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus isolate HC-J4 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.11 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1170959 | — | — | 1 | 6.16 |
| CHEMBL1814457 | — | — | 1 | 5.66 |
| CHEMBL1814449 | — | — | 1 | 5.64 |
| CHEMBL1814448 | — | — | 1 | 5.60 |
| CHEMBL1814434 | — | — | 1 | 5.58 |
| CHEMBL1814447 | — | — | 1 | 5.51 |
| CHEMBL203090 | — | — | 1 | 5.44 |
| CHEMBL1814442 | — | — | 1 | 5.42 |
| CHEMBL593229 | AUREUSIDIN | — | 1 | 5.27 |
| CHEMBL1814435 | — | — | 1 | 5.24 |
| CHEMBL1814444 | — | — | 1 | 5.24 |
| CHEMBL199975 | — | — | 1 | 5.23 |
| CHEMBL1814436 | — | — | 1 | 5.01 |
| CHEMBL201626 | — | — | 1 | 5.01 |
| CHEMBL1172319 | — | — | 1 | 5.00 |
| CHEMBL1170960 | — | — | 1 | 4.96 |
| CHEMBL1814451 | — | — | 1 | 4.95 |
| CHEMBL1814450 | — | — | 1 | 4.94 |
| CHEMBL1814433 | — | — | 1 | 4.84 |
| CHEMBL382905 | — | — | 1 | 4.82 |
| CHEMBL1172318 | — | — | 1 | 4.75 |
| CHEMBL201534 | — | — | 1 | 4.48 |
| CHEMBL1172320 | — | — | 1 | 4.43 |
| CHEMBL1814431 | — | — | 1 | 4.43 |
| CHEMBL1814432 | — | — | 1 | 4.25 |
| CHEMBL1811946 | — | — | 1 | - |
| CHEMBL426110 | — | — | 1 | - |
| CHEMBL1170364 | — | — | 1 | - |
| CHEMBL1814456 | — | — | 1 | - |
| CHEMBL1814455 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1170959 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1814457 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1814449 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1814448 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1814434 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1814447 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL203090 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1814442 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL593229 | AUREUSIDIN | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1814435 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1814444 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL199975 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1814436 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL201626 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL1172319 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1170960 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1814451 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL1814450 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1814433 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL382905 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL1172318 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL201534 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1814431 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1172320 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1814432 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL1814437 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814438 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL201510 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814439 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814440 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814441 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814443 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814445 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814446 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814452 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1213666 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814453 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814454 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814455 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1814456 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1170364 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL426110 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1811946 | — | IC50 | > | 20000.0 | nM | - |